Optimizing Care for Hereditary Angioedema: Strategies for Personalizing Treatment Selection and Effective Patient Communication

Format: Webcourse
Credit(s): 1.00 (60 min)
Release Date: May 01, 2019
Expiration Date: May 01, 2020
Credit Type(s):
  • CME / AMA PRA Category 1 Credit™
  • MOC / ABAI MOC Points
  • MIPS Improvement Activity Under MACRA


Hereditary angioedema (HAE) is a rare genetic disease which causes sporadic swelling in the face, neck, limbs, and abdomen. The frequency, severity, and character of attacks can vary widely, and patients with HAE frequently have delayed diagnoses or are misdiagnosed. Effective targeted agents and current evidence-based recommendations on their use are often not considered. Regular monitoring of attacks is necessary to ensure proper care, but is often omitted.

This activity will improve the management of patients with HAE by reviewing current guidelines for the diagnosis of HAE, informing clinicians about the safety and efficacy of approved HAE therapies and recommendations for their use, and outlining the importance of using patient-reporting instruments in monitoring the frequency and severity of HAE episodes and patient quality of life.


Welcome and Introductions
Delays in Referrals of Suspected HAE Cases
Guideline-based Treatment of HAE
Improving Disease Monitoring and Communication Between Physicians and Patients
Q&A Session and Concluding Remarks


This activity is intended for allergists, immunologists, and primary care providers who are involved in the diagnosis and treatment of patients with hereditary angioedema.


At the conclusion of this activity, participants should be able to:

  • Integrate current guidelines for diagnoses of patients with HAE into routine practice
  • Assess current safety and efficacy data of approved therapies for HAE
  • Evaluate the use of patient-reporting instruments (HAE-AS and HAE-QoL) in monitoring treatment response and quality of life


The Potomac Center for Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.


The Potomac Center for Medical Education designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

For information about the accreditation of this program, please email: contact@potomacme.org.


Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS).



Marc Riedl, MD, MS
Professor of Medicine
Clinical Director, US HAEA Angioedema Center
Division of Rheumatology, Allergy & Immunology
University of California, San Diego
San Diego, CA
Marc Riedl, MD, MS is Professor of Medicine and Clinical Director of the US HAEA Angioedema Center at the University of California, San Diego (UCSD), where he also serves as Training Program Director for Allergy-Immunology. He received his medical degree from the University of Chicago-Pritzker School of Medicine, completed his internal medicine residency at Barnes-Jewish Hospital of Washington University in St. Louis, and a clinical immunology and allergy fellowship at UCLA.

Dr. Riedl received a Master of Science degree in clinical research from UCLA and holds board certifications in allergy-immunology and clinical pharmacology. He serves on numerous editorial boards and scientific committees, as well as appointed expert panels for the Food and Drug Administration (FDA) and the National Institutes of Health (NlH). He directs an active clinical research program at UCSD focused on angioedema and immunodeficiency conditions.
Daniel F. Soteres, MD, MPH
Associate Clinical Professor
University of Colorado Health Sciences Center
Physician/Owner, Asthma and Allergy Associates, PC
Denver, CO
Daniel F. Soteres, MD, MPH is a board-certified allergy/immunology physician with offices in Colorado Springs and Pueblo. He has been in private practice at Asthma and Allergy Associates and Research Center since 2005. He is a Clinical Professor on faculty at the University of Colorado Health Sciences Center in Denver and is the Secretary/Treasurer of the Colorado Allergy Asthma Society. His interests in the medical field range from the joy of clinical practice and taking care of patients to the challenges and academic rigor associated with research. He also believes in the importance of community service and he has many volunteer commitments.

Dr. Soteres received his medical degree in 1998 from Tulane University School of Medicine in New Orleans, while simultaneously earning a Master's in Public Health. He completed a four-year combined residency in internal medicine and pediatrics and was a Chief Resident in internal medicine. He completed his allergy and immunology fellowship at Tulane and is board-certified in allergy and immunology.

In the clinic, he diagnoses and treats asthma, exercise-induced asthma, other respiratory problems, environmental and food allergies, skin disorders, and immunologic diseases. He enjoys helping people with ordinary and rare and complicated diseases. Dr. Sorteres has been a primary investigator for studies of asthma, allergy, and hereditary angioedema. He has also studied treatments for COPD and migraine and participates on many national advisory boards.

Volunteer accomplishments include founding a support group for families of kids with severe food allergy called MOSAIC (Mothers of Severely Allergic Infants and Children), organizing a local journal club for allergy doctors in the region, mentoring medical and physician assistant students, and participating in the D20 physician advisory board.


Diplomates of the American Board of Allergy and Immunology (ABAI) must attest to obtaining 25 hours of Allergy/Immunology-specific CME credits from accredited organizations every year in order to fulfill the lifelong learning component of MOC. Participation in this activity will support board certified allergists and immunologists in contributing towards this MOC requirement set forth by the ABAI.

Disclosure Statement

DISCLOSURE The Potomac Center for Medical Education (PCME) adheres to the policies and guidelines, including the Standards for Commercial Support, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous.

All persons in a position to control the content of a continuing medical education program provided by PCME are required to disclose any relevant financial relationships with any commercial interest to PCME as well as to learners. All conflicts of interest are identified and resolved by PCME in accordance with the Standards for Commercial Support in advance of delivery of the activity to learners. The content of this activity was vetted by an external reviewer to assure objectivity and that the activity is free of commercial bias.

Steering Committee Disclosures

The steering committee reported the following relevant financial relationships that they or their spouse/partner have with commercial interests:

Marc Riedl, MD, MS: Consultant/Independent Contractor: Adverum, BioCryst, CSL Behring, Ionis, KalVista, Pharming, Shire; Grant/Research Support: BioCryst, CSL Behring, Pharming, Shire; Speaker's Bureau: CSL Behring, Pharming, Shire

Daniel F. Soteres, MD, MPH: Consultant/Independent Contractor: Ruconest, Shire; Grant/Research Support: BioCryst, CSL Behring, Shire; Speaker's Bureau: CSL Behring, Ruconest, Shire

Non-faculty Content Contributors Disclosures

Non-faculty content contributors and/or reviewers reported the following relevant financial relationships that they or their spouse/partner have with commercial interests:

Terry Ann Glauser, MD, MPH; Blair St. Amand; Ashley Marostica, MSN, RN, CCM; Lindsey Scott, PT, DPT, ATC: Nothing to disclose


The contents of some CME/CE activities may contain discussions of non-approved or off-label uses of some agents mentioned. Please consult the prescribing information for full disclosure of approved uses.


In order to view this presentation, your computer must have audio capabilities (working speakers or headphones) and must have an internet browser capable of playing an HTML5 video.


There is no fee for this activity. To receive credit, participants must take the pre-test, view this CME activity in its entirety, and then complete the post-test, with a score of 80% or better, and evaluation. The estimated time for completion of this activity is 1 hour. To receive their certificates, participants must demonstrate mastery of the presented material via the post-test. Participant is allowed to take the post-test multiple times.


I’ll begin the program today with a brief overview of hereditary angioedema. This is a rare autosomal dominant disease that’s believed to affect approximately one in 50,000 patients. That accounts for about 8,000 people affected by HAE in the United States. The phenotype or disease course of HAE is highly variable and this true between individuals affected by HAE, but also true for a single patient over the course of their lifetime as they may see varying frequency and severity of the angioedema attacks due to HAE. Given this high variability, it’s difficult to estimate the impact of HAE on any individual patient, but studies have shown that generally speaking, untreated patients on average have an attack about every one to two weeks. Additionally, studies have not been able to establish any simple relationship between disease severity and C1 inhibitor levels, or even specific mutations that are causative of HAE so predicting the clinical course for any given patient is quite difficult. For a full transcript, click here.


Provided by the Potomac Center for Medical Education


This activity is supported by educational grants from CSL Behring and Pharming Healthcare, Inc.


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