X-Linked Hypophosphatemia: Improving Clinician Awareness and Management

Format: Webcourse

Credit(s): 1.00 (60 min)

Release Date: Sep 05, 2019

Expiration Date: Sep 05, 2020

Credit Type(s):

CME / AMA PRA Category 1 Credit™
MOC / ABIM MOC Part 2 Credit

PROGRAM OVERVIEW

Treatment for patients with X-linked hypophosphatemia (XLH) has long been hindered by conventional agents’ monitoring requirements, adverse events, and limited efficacy. Fortunately, in April 2018, an FGF23 blocking antibody became the first FDA-approved agent for XLH. However, because XLH remains a rare disease, clinicians may not be properly equipped to recognize and manage it.

This CME activity, X-Linked Hypophosphatemia: Improving Clinician Awareness and Management, will help participants recognize the clinical presentation of XLH, identify the potential short- and long-term complications of XLH, and understand the latest evidence on and role of the recently approved breakthroughs.

AGENDA

Welcome and Introduction
Recognizing XLH and Understanding Its Clinical Manifestations
Managing XLH in Clinical Practice
Q&A Session and Concluding Remarks

TARGET AUDIENCE

This activity is intended for primary care clinicians (e.g. family physicians, pediatricians), the front-line providers likely to first assess and diagnose patients with XLH.

EDUCATIONAL OBJECTIVES

This program is designed to address the following National Academy of Medicine (NAM) competencies: provide patient-centered care and employ evidence-based practice.

At the conclusion of this activity, participants should be able to:

Recognize the clinical presentation of XLH
Identify the potential short- and long-term complications of XLH
Discuss the efficacy and safety data for newly approved agents for XLH
Incorporate clinical data and expert recommendations, which include newly approved therapies in management plans for adolescents and adults with XLH

ACCREDITATION

The Potomac Center for Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION

The Potomac Center for Medical Education designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the
extent of their participation in the activity.

For information about the accreditation of this program, please email: contact@potomacme.org.

FACULTY

Suzanne Jan De Beur, MD
Associate Professor of Medicine
Johns Hopkins University School of Medicine
Baltimore, MD

Suzanne Jan De Beur, MD is Associate Professor of Medicine at the Johns Hopkins University School of Medicine and Director of the Clinical Research Units of the Johns Hopkins Institute for Clinical and Translational Research. She received her BA and her medical doctorate from Cornell University. She completed the Osler Medical Residency at the Johns Hopkins Hospital and her fellowship in endocrinology and metabolism at the Johns Hopkins University School of Medicine.
As a physician-scientist and practicing endocrinologist, Dr. Jan de Beur’s clinical and research work focuses on understanding rare and metabolic bone diseases at the basic level and translating these observations to the bedside. Specifically, her research interests include understanding the physiology of FGF23 and the molecular basis of disorders of phosphate homeostasis, emerging treatments for rare bone diseases, and the genetic basis of parathyroid hormone resistance syndromes. Dr. Jan de Beur has authored numerous peer-reviewed publications, reviews, and book chapters in high-impact journals, including New England Journal of Medicine, Journal of the American Medical Association, Journal of Clinical Investigation, and The Lancet.

Farzana Perwad, MD
Associate Professor
Chief, Division of Nephrology
Director, Pediatric Nephrology Fellowship Program
Director, Scholarship Oversight Committee
University of California San Francisco
Childrens Renal Center
San Francisco, CA

Farzana Perwad, MD is an Associate Professor in the Department of Pediatrics at the University of California San Francisco (UCSF). She is the Division Chief of Pediatric Nephrology at UCSF and her research interests are in the field of bone and mineral disorders related to kidney disease. Specifically, Dr. Perwad’s research focuses on the regulation of vitamin D and phosphorus homeostasis by fibroblast growth factor 23 (FGF23). Her research projects include investigating the pathophysiology of X-linked hypophosphatemia (XLH) in mouse models of XLH, and the molecular mechanisms of action of FGF23 in the kidney.

ABIM MOC DESIGNATION

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

For ABIM MOC points, your information will be shared with the ABIM through PCME's ACCME Program and Activity Reporting System (PARS). Please allow 6-8 weeks for your MOC points to appear on your ABIM records.

ABP PART 2 DESIGNATION

Successful completion of this CME activity, which includes participation in the activity and individual assessment of and feedback to the learner, enables the learner to earn up to 1.0 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

For ABP MOC points, your information will be shared with the ABP through PCME's ACCME Program and Activity Reporting System (PARS). Please allow 6-8 weeks for your MOC points to appear on your ABP records.

AAFP DESIGNATION

This Enduring Material activity, X-Linked Hypophosphatemia: Improving Clinician Awareness and Management, has been reviewed and is acceptable for up to 1.00 Prescribed credit(s) by the American Academy of Family Physicians. AAFP certification begins 09/05/2019. Term of approval is for one year from this date. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

DISCLOSURE

The Potomac Center for Medical Education (PCME) adheres to the policies and guidelines, including the Standards for Commercial Support, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous.

All persons in a position to control the content of a continuing medical education program provided by PCME are required to disclose any relevant financial relationships with any commercial interest to PCME as well as to learners. All conflicts of interest are identified and resolved by PCME in accordance with the Standards for Commercial Support in advance of delivery of the activity to learners. The content of this activity was vetted by an external reviewer to assure objectivity and that the activity is free of commercial bias.

FACULTY DISCLOSURES

Suzanne Jan De Beur, MD: Consultant/Independent Contractor: Ultragenyx; Grant/Research Support: Ultragenyx

Farzana Perwad, MD: Speaker’s Bureau: Ultragenyx

NON-FACULTY CONTENT CONTRIBUTORS

Nicolle Rochino, PharmD, RPh; Blair St. Amand; Lindsay Scott, PT, DPT, ATC; Ashley Marostica, MSN, RN, CCM; Brian Jack, MD: Nothing to disclose

FDA DISCLOSURE

The contents of some CME/CE activities may contain discussions of non-approved or off-label uses of some agents mentioned. Please consult the prescribing information for full disclosure of approved uses.

SYSTEM REQUIREMENTS

In order to view this presentation, your computer must have audio capabilities (working speakers or headphones) and must have an internet browser capable of playing an HTML5 video.

INSTRUCTIONS FOR PARTICIPANTS AND OBTAINING CME CREDIT

There is no fee for this activity. To receive credit, participants must take the pre-test, view this CME activity in its entirety, and then complete the post-test, with a score of 80% or better, and evaluation. The estimated time for completion of this activity is 1 hour. To receive their certificates, participants must demonstrate mastery of the presented material via the post-test. Participant is allowed to take the post-test multiple times.